JANIA TOLTERODINE 2MG 14TABS

The recommended dose is 4 mg once daily with water and swallowed whole. The dose may be lowered to 2 mg daily based on individual response and tolerability or as directed by your physician.

Side Effects

Dry mouth , Headache , Constipation , Stomach pain .

Drug Interactions

Potent CYP2D6 Inhibitors e.g. Fluoxetine , Potent CYP3A4 Inhibitors e.g. Ketoconazole , itraconazole, clarithromycin, or ritonavir .

Indication

It is indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency .

When not to Use

It is contraindicated in patients with urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma.It is also contraindicated in patients with known hypersensitivity to the drug or its ingredients, or to fesoterodine fumarate extended-release tablets which, like Tolterodine Tartrate, are metabolized to 5-hydroxymethyl tolterodine .

Precautions

Precaution

Anaphylaxis and angioedema requiring hospitalization and emergency medical treatment have occurred with the first or subsequent doses of Tolterodine Tartrate. In the event of difficulty in breathing, upper airway obstruction, or fall in blood pressure, it should be discontinued and appropriate therapy promptly provided.

Warnings

Warning 1

Administer Tolterodine Tartrate with caution to patients with clinically significant bladder outflow obstruction because of the risk of urinary retention .

Warning 2

Administer Tolterodine Tartrate with caution in patients with gastrointestinal obstructive disorders because of the risk of gastric retention. Tolterodine Tartrate , like other antimuscarinic drugs, may decrease gastrointestinal motility and should be used with caution in patients with conditions associated with decreased gastrointestinal motility (e.g., intestinal atony) .

Warning 3

Tolterodine Tartrate is associated with anticholinergic central nervous system (CNS) effects including dizziness and somnolence . Patients should be monitored for signs of anticholinergic CNS effects, particularly after beginning treatment or increasing the dose. Advise patients not to drive or operate heavy machinery until the drug’s effects have been determined. If a patient experiences anticholinergic CNS effects, dose reduction or drug discontinuation should be considered.

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