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Description

Pargeverine hydrochloride is a rapidly absorbed drug. It is metabolized in the body without its metabolites having been identified, which are excreted through bile and urine.

The elimination process is relatively fast, so that it is necessary to administer repeated doses every 8 hours.

The antispasmodic effect of pargeverine hydrochloride derives from its antimuscarinic and musculotropic action. Due to its action on the contracted or distended myofibril, Pargeverine has a spasmolytic effect and is useful in the treatment of all painful visceral syndromes whose main component is the spasm of the smooth muscles located in any portion of the digestive tract of the bile ducts of the urinary tract or female genital tract.

Lysine clonixinate is a non-narcotic pain reliever, derived from anthranilic acid. It inhibits the enzyme prostaglandin synthetase, responsible for the synthesis of prostaglandins.

The prostaglandins PGE and PGF2 are directly responsible for the stimulation of pain neuroreceptors; Lysine clonixinate, by blocking its production, prevents the uptake of painful sensitivity, regardless of the cause, intensity and location. Lysine clonixinate has also been shown to inhibit bradycin and PGF2, already produced by what is considered a direct antagonist of pain mediators.

Lysine clonixinate has an analgesic effect, without altering the vital signs or the state of consciousness of the patients, since it is a non-narcotic analgesic. 125 mg dose of lysine clonixinate is 23.6 times higher than acetylsalicylic acid and 10 times higher compared to metamizole.

It does not depress the bone marrow or interfere with clotting factors, so it does not alter bleeding time.

Lysine clonixinate is rapidly and completely absorbed in the stomach, starting its activity within the first 10 to 15 minutes after ingestion, reaching maximum serum concentrations at the time of administration. It is not deposited in the gastric mucosa, therefore it has a minimal ulcerogenic index. It is widely distributed in all tissues. It is partially metabolized in the liver and is eliminated via the urine.

In those cases in which the differential diagnosis between visceral pain and somatic pain is imprecise or when both overlap, Pargeverine, lysine clonixinate, exerts antispasmodic and analgesic effects, normalizing myotone and visceral motility.

Pargeverine, Lysine Clonixinate, exerts an analgesic effect on the affected areas and reflex zones, effectively blocking the visceral spasm-pain cycle.