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DYMISTA® D Suspension: In 4 clinical studies in adults and adolescents with allergic rhinitis, DYMISTA® D Suspension, administered one spray into each nostril twice daily, improved nasal symptoms (comprising rhinorrhea, nasal congestion, sneezing, and nasal itching) compared to placebo, Azelastine hydrochloride alone, and Fluticasone Propionate alone. The compound significantly improved ocular symptoms (irritation, tearing/wetting, and eye redness) as well as disease-related quality of life (Rhinoconjunctivitis Quality of Life Questionnaire-ROLO) in all 4 studies.

Compared to marketed Fluticasone Propionate nasal spray preparations, symptom improvement (50% reduction in severity of nasal symptoms) was achieved significantly sooner (3 days or more) with DYMISTA® D Suspension. The superior effect of DYMISTA® D Suspension against Fluticasone Propionate was maintained over one year in patients with chronic persistent allergic rhinitis and non-allergic/vasomotor rhinitis.